PATHOMORPHOLOGICAL CHARACTERISTICS OF RENAL CHANGES IN FATAL CASES OF PREECLAMPSIA: A COMPREHENSIVE ANALYSIS
Abstract
Preeclampsia remains a leading cause of maternal morbidity and mortality worldwide, posing significant challenges to maternal health. Renal involvement is a hallmark feature of severe preeclampsia, often contributing to adverse outcomes. This thesis investigates the pathomorphological characteristics of renal changes in pregnant women who succumbed to preeclampsia, aiming to enhance our understanding of the renal pathophysiology underlying this condition. Through a systematic review and detailed analysis of histopathological findings from autopsies and biopsies, this study elucidates the spectrum of renal lesions observed in fatal cases of preeclampsia. Furthermore, it explores potential mechanisms underlying these pathological changes, including endothelial dysfunction, glomerular injury, and vascular remodeling. The findings of this thesis provide valuable insights into the complex interplay between pregnancy-related factors and renal pathology in preeclampsia, facilitating the development of targeted diagnostic and therapeutic strategies to improve maternal outcomes.
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