EKSPERIMENTAL TIREOTOKSIKOZDA MOYAK BURALMA NAYCHALARINING STRUKTURAVIY O’ZGARISHLARI VA ULARNI EFIR MOYLARI BILAN HIMOYALASHNING ZAMONAVIY USULLARI
Keywords:
Kalit soʼzlar: Kalamush, moyaklar, tireotoksikoz, buralma naychalar, merkazolil, qushqo’nmas moyi, zaytun moyi,Abstract
Asosnoma: Qalqonsimon bez gormonlari ko'p fiziologik faoliyatda muhim rol o'ynaydi, shu jumladan hayvonlarning reproduktiv funksiyasi to'g'ri ishlashida, ularning rivojlanishini nazorat qilishda qatnashadi. Qalqonsimon bez gormonlarining ortiqchaligi yoki etishmasligi moyaklar funksiyasining o'zgarishiga olib keladi. Tireotoksikoz modeli chaqirilgan kalamushlarni va ularni an`anaviy hamda noan`anaviy davolashda moyak buralma naychalari soni, naychalar epitelial qalinligi qanday o’zgarishga uchrashi aniqlandi. Barcha tajriba guruh hayvonlarini nazorat guruhiga solishtirilganda moyak buralma naychalar soni va buralma naychalar diametri diyarli o’zgarmagan, merkazolil va qushqo’nmas moyi qo’shilgan tajriba guruhda buralma naychalar bo’shlig’ining diametri merkazolil yuborilgan tajriba guruhga nisbatan kamayib yaxshilandi, merkazolil va zaytun moyi berilgan hayvonlar guruhda esa ikkinchi (merkazolil) tajriba guruhga solishtirganda buralma naychalar epitelial qavatining balandligi sezilarli tiklanganligi aniqlandi.
References
Smith LB, Walker WH. Regulation of spermatogenesis by androgens. Semin Cell Dev Biol (2014) 30:2–13. doi: 10.1016/j.semcdb.2014.02.012
Legacki E, Conley AJ, Nitta-Oda BJ, Berger T. Proliferation of porcine Sertoli cells after androgen receptor inactivation. Biol Reprod (2015) 92(4):93. doi: 10.1095/biolreprod.114.125716
Sandro La Vignera and Roberto Vita Thyroid dysfunction and semen quality International Journal of Immunopathology and Pharmacology , Volume 32, March-December 2018 The Author(s) 2018 https://doi.org/10.1177/2058738418775241
Bader OA, Hussein HN. The effects of thyroidectomy on healing racture in rabbits model. Iraqi J Vet Sci. 2022;36(3):563-570. DOI: 10.33899/ijvs.2021.130893.1897.
Silva JF, Ocarino NM, and Serakides R. Thyroid hormones and female reproduction, Biol Reprod. 2018;99(5):907-921. DOI:10.1093/biolre/ioy115
Hanhao Shi, Nazar Ali Korejo, Asghar Ali Kamboh, Rashid Ali Korejo, Fangxiong Shi Effects of hyperthyroidism and diabetes mellitus on spermatogenesis in peri- and post-pubertal mice Front Endocrinol (Lausanne) 2023 Aug 15:14:1191571. doi: 10.3389/fendo.2023.1191571. Collection 2023.
Romano RM, Gomes SN, Cardoso NC, et al. (2017) New insights for male infertility revealed by alterations in spermatic function and differential testicular expression of thyroid-related genes. Endocrine 55(2): 607–617.
Rijntjes E, Gomes MLM, Zupanic N, et al. (2017) Transient hypothyroidism: Dual effect on adult-type Leydig cell and Sertoli cell development. Frontiers in Physiology 8: 323.
