THE KEY TO THE EFFECTIVENESS AND SAFETY OF PHARMACOTHERAPY
Keywords:
Key words: CYP2C19 gene, CYP2C19 G681A polymorphism, chronic gastritis, genotyping, personificationAbstract
The article discusses the issues of genotyping patients with chronic gastritis (CG) for the *2(G681A) polymorphism of the CYP2C19 gene, characterized by the replacement of guanine (G) with adenine (A) at position 681 (rs4244285) in exon 5. The CYP2C19 gene encodes the CYP2C19 isoenzyme, which metabolizes proton pump inhibitors (PPI) - first-line drugs in the pharmacotherapy of CG. The author recommends the choice of drug and its dose depending on the genotypic affiliation of the patient - personification, which ensures the effectiveness and safety of treatment.
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