METABOLISM REGULATOR IN PATIENTS WITH CHRONIC HEART FAILURE AND ANEMIA OF CHRONIC DISEASES
Keywords:
Key words: hepcidin, chronic heart failure, anemia of chronic diseases, elderly and senile age.Abstract
Goal. To study the role of hepcidin as a regulator of iron metabolism and a mediator of inflammation in elderly and senile patients with chronic heart failure (CHF) and anemia of chronic diseases (ACD).
Material and methods. In 14 patients with CHF with ACD, 14 patients with CHF without anemia and 8 patients without CHF and anemia (control group) of elderly and senile age, the levels of hemogram parameters, ferrokinetics (serum iron, ferritin, transferrin, erythropoietin, hepcidin), inflammation [C-reactive protein (CRP), interleukin-6 (IL-6)] and the relationship between hepcidin and the named indicators.
Results. In patients of the control group, normal levels of hepcidin (9.17±0.97 ng/ml) and the only significant association of hepcidin with ferrokinetics were revealed – serum iron (r(S)=0.480, p=0.032). In the CHF group without anemia, normal levels of hepcidin (12.01±1.19 ng/ml) and two significant associations of hepcidin with ferrokinetics were also revealed – ferritin [r(S)=0.525, p=0.001] and transferrin [r(S)=- 0.343, p=0.044]. In the CHF group with ACD, significantly elevated levels of hepcidin were detected (23.81±3.63ng/ml) relative to CHF without anemia (p=0.008) and the control group (p=0.003) and five significant correlations of hepcidin with hemogram parameters – hemoglobin [r(S)=-0.461, p=0.043] and the average concentration of hemoglobin in the erythrocyte [r(S)=-0.437, p=0.009]; ferrokinetics – ferritin [r(S)=0.596, p<0.0001] and transferrin [r(S) =-0.474, p=0.004]; inflammation – CRP [r(S)=0.561, p<0.0001].
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