HERBAL PREPARATIONS FROM MILK THISTLE: MECHANISMS OF ACTION AND APPLICATION IN LIVER DISEASES
Keywords:
Key words: Milk Thistle, silymarin, hepatoprotective properties, hepatitis, liver cirrhosis.Abstract
Herbal preparations from Milk Thistle possess documented hepatoprotective properties. Nowadays the increase of interest to this herbal drug is connected with the prevalence of different forms of liver pathology and with the discovery of new properties of its active components. This review contains information on pharmacology, mechanism of action, efficiency of Milk Thistle preparations applications in liver diseases and demonstrates possibilities of their using in other pathological states.
References
Pharmacology of Silymarin / F. Fraschini [et al.] // Clin. Drug Invest. — 2002. — Vol. 22, № 1. — P. 51–65.
Silymarin treatment of viral hepatitis: a systematic review / K. E. Mayer [et al.] // Journal of Viral Hepatitis. — 2005. — Vol. 12. — P. 559–567.
Kren, V. Silybin And Silymarin — new effects and applications / V. Kren, D. Walterova // Biomed. Papers. — 2005. — Vol. 149, № 1. — P. 29–41.
Pharmacokinetic studies with silymarin in human serum and bile / D. Lorenz [et al.] // Methods Find. Exp. Clin. Pharmacol. — 1984. — Vol. 6, № 10. — P. 655–661.
Pradhan, S. C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine / S. C. Pradhan, C. Girish // Indian J. Med. Res. — 2006. — Vol. 124, № 5. — P. 491–504.
Effect of free radical scavengers on superoxide dismutase (SOD) enzyme in patients with alcoholic cirrhosis / J. Feher [et al.] // Acta Medica Hungarica. — 1988. — Vol. 45, № 3/4. — P. 265–276.
Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver / R. Campos [et al.] // Planta Med. — 1989. — Vol. 55, № 5. — P. 417–419.
Sonnenbichler, J. Mechanism of action of silibinin. V. Effect of silibinin on the synthesis of ribosomal RNA, mRNA and tRNA in rat liver in vivo / J. Sonnenbichler, I. Zetl // Hoppe Seylers Z Physiol. Chem. — 1984. — Vol. 365, № 5. — P. 555–566.
Mukhammadieva Musharraf Ibrokhimovna. (2023). IMPROVING THE PREVENTION AND TREATMENT OF COMPLICATIONS OF SPONTANEOUS BACTERIAL PERITONITIS IN PATIENTS WITH LIVER CIRRHOSIS OF VIRAL ETIOLOGY. Galaxy International Interdisciplinary Research Journal, 11(4), 388–394. Retrieved from https://giirj.com/index.php/giirj/article/view/5168
A. R., O., M. I., M., & B. O., K. (2024). Improvement of Primary Prophylaxis and Treatment of Spontaneous Bacterial Peritonitis Complicated in Virus Etiology Liver Cirrhosis. International Journal of Integrative and Modern Medicine, 2(5), 85–91. Retrieved from https://medicaljournals.eu/index.php/IJIMM/article/view/303
Mukhammadieva Musharraf Ibrokhimovna. (2024). TREATMENT OF SPONTANEOUS BACTERIAL PERITONITIS COMPLICATED IN VIRUS ETIOLOGY LIVER CIRRHOSIS. JOURNAL OF EDUCATION, ETHICS AND VALUE, 3(6), 73–80. Retrieved from https://jeev.innovascience.uz/index.php/jeev/article/view/723
Abdulloev Mukhriddin Ziyodulloevich. (2023). Modern Therapy of Viral Hepatitis. Texas Journal of Medical Science, 26, 66–69. Retrieved from https://www.zienjournals.com/index.php/tjms/article/view/4636
Abdulloev Mukhriddin Ziyodulloevich. (2023). Modern Therapy of Viral Hepatitis. Texas Journal of Medical Science, 26, 66–69. Retrieved from https://www.zienjournals.com/index.php/tjms/article/view/4636
Mukhammadieva M.I. (2023). Вирус этиологияли жигар циррози беморларида спонтан бактериал перитонит билан асоратланишнинг профилактикаси ва давосини такомиллаштириш//Oriental Renaissance: Innovative, educational, natural and social sciences. -2023.-P.947-953.
Oblokulov A.R., M.I.Mukhammadieva.(2022). Clinical and biochemical characteristics of liver cirrhosis patients of viral etiology with spontaneous bacterial peritonitis//Academicia Globe: Indersciense Research.-2022.- P. 210-216.
Elmurodova A.A. (2023). Viral Hepatitis Delta: An Underestimated Threat. Texas Journal of Medical Science, 26, 1–3. https://doi.org/10.62480/tjms.2023.vol26.pp1-3
Elmurodova , A. . (2023). ROLE OF CYTOKINES IN THE DEVELOPMENT OF LIVER CIRRHOSIS, WHICH DEVELOPED AS A RESULT OF CHRONIC VIRAL HEPATITIS D. Евразийский журнал медицинских и естественных наук, 3(11), 217–221. извлечено от https://in-academy.uz/index.php/EJMNS/article/view/23842
A., E. A. (2022). Specific Features of the Hemostatic System in Covid-Central Asian Journal of Medical and Natural Science, 3(2), 82-85. https://doi.org/10.17605/cajmns.v3i2.627
Elmurodova, A. A. (2021). Significance of Clinical Symptoms in Assessing the Severity and Prognosis of the Course of Crimean-Congo Hemorrhagic Fever. Central Asian Journal of Medical and Natural Science, 35-37.
Авазовна, С. С. . (2023). Факторы Развития Гепаторенального Синдрома У Больных Циррозом Печени Вирусной Этиологии. AMALIY VA TIBBIYOT FANLARI ILMIY JURNALI, 2(12), 1–8. Retrieved from https://www.sciencebox.uz/index.php/amaltibbiyot/article/view/8673
Санокулова, Ситора Авазовна ОCOБЕННОСТИ ТЕЧЕНИЯ КОНТОГИОЗНЫХ ГЕЛЬМИНТОВ АССОЦИИРОВАННОГО С ЛЯМБЛИОЗОМ // ORIENSS. 2023. №2. URL: https://cyberleninka.ru/article/n/ocobennosti-techeniya-kontogioznyh-gelmintov-assotsiirovannogo-s-lyambliozom (дата обращения: 12.12.2023).
Jalilova, А.S. (2022). THE SPREAD OF CIRRHOSIS OF THE LIVER BY ETIOLOGICAL FACTORS. Oriental renaissance: Innovative, educational, natural and social sciences, 2 (6), 253-257.
Ibrokhimovna, M. M. (2024). Improvement of Primary Prophylaxis and Treatment of Spontaneous Bacterial Peritonitis Complicated in Virus Etiology Liver Cirrhosis. Journal of Intellectual Property and Human Rights, 3(4), 19-25.
Облоқулов, А., & Муҳаммадиева, М. (2022). КЛИНИКО-ЛАБОРАТОРНАЯ ХАРАКТЕРИСТИКА СПОНТАННОГО БАКТЕРИАЛЬНОГО ПЕРИТОНИТА ПРИ ЦИРРОЗЕ ПЕЧЕНИ ВИРУСНОЙ ЭТИОЛОГИИИ. Журнал вестник врача, 1(3), 66–69. извлечено от https://inlibrary.uz/index.php/doctors_herald/article/view/2016
Oblokulova Z.I, Oblokulov A.R, & Jalilova A.S. (2022). Diagnostic Significance of Hepatic Fibrosis in Patients with Extrahepatic Chronic Viral Hepatitis C. Central Asian Journal of Medical and Natural Science, 3(3), 438-443. Retrieved from https://www.cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/806
Aslonova.M.R. (2022). Determination of suicidality against the background of Parasitic Diseases in children // INTERNATIONAL JOURNAL OF PHILOSOPHICAL STUDIES AND SOCIAL SCIENCES. – 2022.- P. 9-12.
Jalilova, A. S. (2022). Approaches to Etiotropic Therapy of Covid-19 in Outpatient Patients. INTERNATIONAL JOURNAL OF HEALTH SYSTEMS AND MEDICAL SCIENCES, 1(1), 41-44.
Mukhtarova Sh.A. (2022) Age-related features of clinical manifestations of giardiasis // International journal of medical sciences and clinical research 2022;17-21.
Jalilova A.S. (2022). FEATURES OF CLINICAL MANIFESTATIONS OF CYTOMEGALOVIRUS INFECTION IN CHILDREN. International Journal of Medical Sciences And Clinical Research, 2(09), 12–16. https://doi.org/10.37547/ijmscr/Volume02Issue09-04
