REVMATOID ARTRIT KASALLIGIDA SELEKOKSIB (SELETOR) PREPARATINING SAMARADORLIGINI BAHOLASH

Authors

  • Miraxmedova X.T.
  • Solixov B.M.

Keywords:

Kalit so‘zlar: revmatoid artrit, metotreksat, selekoksib.

Abstract

Maqsad: Revmatoid artrit bilan kasallangan bemorlarda selekoksib (seletor) bilan olib borilgan terapiyani samaradorligini baholash.

Material va usullar: Kuzatuvdagi bemorlar ikki guruhga bo‘lib o‘rganildi. Birinchi guruh 25 nafar bemorlar yallig‘lanishga qarshi bazis davo sifatida haftasiga 10 mg metotreksat va ikkinchi guruh 25 nafar bemorlarga esa yallig‘lanishga qarshi bazis davo maqsadida haftasiga 10 mg metotreksat bilan birgalikda sutkasiga 200 mgdan 2 mahal selekoksib (seletor) preparati buyurildi.

Natijalar: Kuzatuvdagi II guruhdagi selekoksib bilan davolangan bemorlarimizda yallig‘langan va og‘riqli bo‘g‘imlar soni, ECHT, C-reaktiv oqsil, VASH, DAS-28 shklalari va HAQ indeksi kamayishi I guruhga nisbatan ishonchli bo‘ldi. 

References

Bullock J, Rizvi SAA, Saleh AM, Ahmed SS, Do DP, Ansari RA, Ahmed J. Rheumatoid Arthritis: A Brief Overview of the Treatment. Med Princ Pract. 2018;27(6):501-507.

Klareskog L, Rönnelid J, Saevarsdottir S, Padyukov L, Alfredsson L. The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis. J Intern Med. 2020 May;287(5):514-533.

Derksen VFAM, Huizinga TWJ, van der Woude D. The role of autoantibodies in the pathophysiology of rheumatoid arthritis. Semin Immunopathol. 2017 Jun;39(4):437-446.

Chaudhari K, Rizvi S, Syed BA. Rheumatoid arthritis: current and future trends. Nat Rev Drug Discov. 2016 May;15((5)):305–6.

Smolen JS, Landewé R, Breedveld FC, Dougados M, Emery P, Gaujoux-Viala C, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis. 2010 Jun;69((6)):964–75.

Fidahic M, Jelicic Kadic A, Radic M, Puljak L. Celecoxib for rheumatoid arthritis. Cochrane Database of Systematic Reviews 2017, Issue 6. Art. No.: CD012095.

Garner S, Fidan D, Frankish R, Judd M, Shea B, Towheed T, Wells G, Tugwell P. Celecoxib for rheumatoid arthritis. Cochrane Database Syst Rev. 2022; (4): CD003831.

https://www.rlsnet.ru/drugs/celekoksib-50352

Chan FKL, Lanas A, Scheiman J, Berger MF, Nguyen H, Goldstein JL. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR):a randomised trial. Lancet 2010;376(9736):173‐9.

Goldstein JL, Correa P, Zhao WW, Burr AM, Hubbard RC, Verburg KM, et al. Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase‐2 inhibitor, compared to naproxen in patients with arthritis. American Journal of Gastroenterology 2001;96(4):1019‐27.

Published

2024-08-20

How to Cite

Miraxmedova X.T., & Solixov B.M. (2024). REVMATOID ARTRIT KASALLIGIDA SELEKOKSIB (SELETOR) PREPARATINING SAMARADORLIGINI BAHOLASH. Journal of New Century Innovations, 59(1), 76–81. Retrieved from https://newjournal.org/new/article/view/16015