THE ROLE OF INTERLEUKIN-6 (IL-6) IN THE PATHOGENESIS OF TYPE 2 DIABETES MELLITUS
Keywords:
Keywords: type 2 diabetes mellitus, IL 6, molecular mechanisms, phosphorylation, insulin, socs3, ri-1.Abstract
Abstract: Interleukin-6 (IL-6) is a pro-inflammatory cytokine that induces the
development of insulin resistance and underlies the pathogenesis of type 2 diabetes
mellitus (DM2), through the generation of inflammation by controlling differentiation,
migration, proliferation, and apoptosis of cells. The presence of IL-6 in tissues is
normal, but its irregular production and prolonged exposure lead to the development
of inflammation, which induces insulin resistance. There is a mechanistic relationship
between IL-6 stimulation and insulin resistance. IL-6 causes insulin resistance by
disrupting the phosphorylation of the insulin receptor and the substrate of the insulin-
1 receptor, inducing the expression of SOCS-3, a potential inhibitor of insulin
signaling.
